Research has called into question the safety and efficacy of garcinia cambogia and HCA supplements. Garcinia cambogia and its main organic acid HCA are popular dietary supplements used to boost weight loss. Although the companies that market these products promise rapid weight loss, research shows that garcinia cambogia and HCA promote minimal fat loss at best. If you have extra weight to lose, skip the garcinia cambogia supplement and instead get healthier by making sustainable dietary and lifestyle modifications that support your overall health and help you reach your goals safely.
A supplement produced from an exotic fruit, garcinia cambogia, is the latest weight-loss craze. But the Internet and television are filled with…. Both garcinia cambogia and apple cider vinegar are claimed to promote weight loss. This article reviews the evidence behind combining garcinia…. Thermogenic supplements are marketed as an easy way to burn fat, but people wonder if they really work. This article reviews the most popular…. This is a detailed, evidence-based review of the 12 most popular weight loss pills and supplements on the market today.
This is a science-based review of Hydroxycut, one of the world's most popular weight loss supplements. It contains caffeine and several herbal…. This simple 3-step plan can help you lose weight fast. Read about the 3-step plan, along with other science-backed weight loss tips, here.
Though losing pounds may seem like an intimidating goal, it can be done by making diet and lifestyle adjustments. Here are 10 tips to help you…. Getting good quality sleep is an important part of weight loss. Here are a few ways sleep can help you lose weight. Health Conditions Discover Plan Connect.
The substance presents a risk for people with a history of coronary artery disease , congestive heart failure , abnormal heart rhythms, or stroke. For long-term, meaningful weight loss, Heymsfield advises against taking garcinia cambogia. Besser also advises her patients to avoid garcinia cambogia in addition to other weight loss supplements. Rahnama has a more open view on the supplement. Garcinia cambogia is not a magic bullet where you can eat all you want. By subscribing you agree to the Terms of Use and Privacy Policy.
References Dietary Supplements for Weight Loss. November 1, Garcinia Cambogia. National Center for Complementary and Integrative Health. September 24, July Journal of Obesity. Evidence-Based Complementary and Alternative Medicine. Phytotherapy Research. June Explant pathology demonstrated near total hepatic necrosis with massive hepatocellular dropout and mixed inflammatory cell infiltrates.
Patient received liver transplantation with complete resolution of symptoms. Acute liver failure and severe hepatotoxicity has been associated multiple dietary supplements utilized for weight loss.
Garcinia cambogia - tree grown in southwestern India. Extracts from the rind of the fruit from this tree are high in hydroxycitric acid and are marketed as weight-loss supplements. Careful questioning of any patient presenting with liver function abnormalities or acute liver failure should prompt questioning regarding dietary supplement and energy drink consumption.
Patients with acute liver failure should be promptly referred to a transplant center for treatment. This article presents one of the first known cases of hepatotoxicity associated with intake of the dietary supplement Garcinia cambogia.
Reviewers felt the article was timely and well written. They requested additional information regarding dosage of the supplement as well as some additional discussion regarding its effects. Manuscript source: Unsolicited manuscript. Specialty type: Gastroenterology and hepatology.
Country of origin: United States. Peer-review report classification. Grade A Excellent : 0. Grade B Very good : B, B. Institutional review board statement: This is a case report, which, per the policies of the Institutional Review Board at the University of California, Los Angeles, is exempt from review. Informed consent statement: The patient presented in this case report gave his written informed consent authorizing use and disclosure of his protected health information.
Conflict-of-interest statement: The authors report no conflicting interests including but not limited to commercial, personal, political, intellectual or religious interests relating to the present manuscript. Peer-review started: April 27, First decision: June 20, Article in press: August 5, National Center for Biotechnology Information , U.
Journal List World J Gastroenterol v. World J Gastroenterol. Published online Dec 7. Author information Article notes Copyright and License information Disclaimer. Keri E Lunsford, J. Published by Baishideng Publishing Group Inc. All rights reserved. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. This article has been cited by other articles in PMC.
Abstract Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Keywords: Dietary supplements, Fulminant hepatic failure, Drug-induced liver injury, Liver transplantation, Hyroxycitric acid, Weight-loss supplements.
Table 1 Work-up for causes of acute liver failure in reported patient. Open in a separate window. Figure 1. COMMENTS Case characteristics The patient initially presented with symptoms of nausea, vomiting, abdominal pain, and symptoms progressed to include confusion, coagulopathy, and jaundice.
Clinical diagnosis Evaluation for viral, genetic, and antibody mediated causes of hepatitis were largely negative with histological evidence of near total hepatic necrosis on biopsy. Differential diagnosis Alternative autoimmune, viral, and genetic causes of acute liver failure must be excluded. Laboratory diagnosis Negative laboratory evaluation for autoimmune, viral, and genetic causes of acute liver failure in the presence of elevated liver function tests and coagulopathy should raise clinical suspicion for drug-induced liver injury.
Imaging diagnosis Magnetic resonance imaging with Eovist contrast demonstrated interval development of heterogeneous, enhancing nodularity with portal venous washout, unlikely to be an infiltrative tumor process. Pathological diagnosis Explant pathology demonstrated near total hepatic necrosis with massive hepatocellular dropout and mixed inflammatory cell infiltrates. Treatment Patient received liver transplantation with complete resolution of symptoms.
Related reports Acute liver failure and severe hepatotoxicity has been associated multiple dietary supplements utilized for weight loss. Garcinia cambogia contains a compound called hydroxycitric acid HCA that may inhibit an enzyme that helps your body store fat. Theoretically, the fat would instead be burned as calories. Allegedly, garcinia cambogia can increase the levels of the neurotransmitter serotonin, a feel-good messenger in your body.
This may enhance your mood and reduce stress-related eating. The first rigorous research on the effectiveness of garcinia cambogia was conducted in A research review showed that it can cause short-term weight loss, but the effect was small and the studies were flawed.
Garcinia cambogia can be found in Hydroxycut. The Food and Drug Administration FDA issued a consumer warning in cautioning consumers to immediately stop using Hydroxycut products after reports of jaundice and extreme liver damage in people who used Hydroxycut surfaced. Other health problems associated with Hydroxycut included seizures, cardiovascular disorders, and rhabdomyolysis. A study from Japan found that rats fed high doses of garcinia cambogia lost significant fat.
However, the high doses also caused testicular atrophy. In , pop television doctor Mehmet Oz announced to his audience that garcinia cambogia is a revolutionary fat buster. No Diet. No Effort. In June , Dr.
0コメント